Phosphorylation regulates IDP folding

Phosphorylation Regulates SIRT1 Function

BACKGROUND SIR2 is an NAD(+)-dependent deacetylase [1]-[3] implicated in the regulation of lifespan in species as diverse as yeast [4], worms [5], and flies [6]. We previously reported that the level of SIRT1, the mammalian homologue of SIR2 [7], [8], is coupled to the level of mitotic activity in cells both in vitro and in vivo[9]. Cells from long-lived mice maintained SIRT1 levels of young mi...

Tyrosine Phosphorylation of CD13 Regulates

Histone core phosphorylation regulates DNA accessibility 1 Histone Core Phosphorylation Regulates DNA Accessibility

Nucleosome unwrapping dynamics provide transient access to the complexes involved in DNA transcription, repair and replication, while regulation of nucleosome unwrapping modulates occupancy of these complexes. Histone H3 is phosphorylated at Tyrosine 41 (H3Y41ph) and Threonine 45 (H3T45ph). H3Y41ph is implicated in regulating transcription, while H3T45ph is involved in DNA replication and apopt...

IDP - An Interactive Discourse Planner

We are building a system that plans text to describe and justify domain plans interactively. This paper focuses on the second task, plan justiication. A speaker uses plan justiication to have a listener adopt a recommended plan. The text plan that our system incremen-tally formulates and executes to justify its recommendation is represented uniformly in the same knowledge base with the domain p...

JONSSON ALGEBRAS AND idp ( ¯ C, Ī)

We improve some theorems of Shelah on the existence of Jonsson algebras on successors of singular cardinals.